Environmental elimination estimate and literature review of ecotoxicological aspects of the main widely used antiretrovirals in Brazil

Objective: To estimate the consumption and quantity of unaltered antiretrivirals (ARV) eliminated into environment to carry out a literature research on aquatic ecotoxicological studies ARV used in Brazil. Methodology: We requested from one dispensing units city Belo-Horizonte (BH) amount dispensed years 2018-2019-2020. Considering 2020, daily dose, elimination rate, drug unchanged form was estimated. For entire municipality BH Brazil, we epidemiological data were regarding individuals using antiretroviral therapy (ART) proportion people living with HIV main ART regimen, following same estimation methodology previously. Structured individual searches carried for each relating it ecotoxicology, through Google Scholar, National Center Biotechnology Information Scifinder, addition use fass.se platform. Results: Four articles presented results acute or chronic toxicity models involving ARV. Dolutegravir efavirenz found be highly toxic models. In approximately 2,167kg ARVs released BH. Brazil 112,274kg. Conclusion: It is urgent quantify water bodies. With these together will possible establish risk criteria measures control mitigate contaminants environment, especially actions improve wastewater/water treatment.